Sodium cloxacillin monohydrate
Sodium cloxacillin monohydrate
CAS: 7081-44-9
Molecular Formula: C19H17ClN3NaO5S·H2O
Sodium cloxacillin monohydrate - Names and Identifiers
Sodium cloxacillin monohydrate - Physico-chemical Properties
| Molecular Formula | C19H17ClN3NaO5S·H2O |
| Molar Mass | 475.88 |
| Melting Point | 170℃ |
| Boling Point | 689℃ |
| Flash Point | >110°(230°F) |
| Water Solubility | Soluble in water |
| Solubility | Easily soluble in water, soluble in ethanol, slightly soluble in chloroform. |
| Appearance | White powder or crystalline powder |
| Storage Condition | 2-8℃ |
| MDL | MFCD00150735 |
| Physical and Chemical Properties | White powder or crystalline powder. Melting point 170 °c (decomposition). Soluble in water, soluble in ethanol, slightly soluble in chloroform, hygroscopicity, odor, bitter taste. |
| Use | The use of the product is a semi-synthetic antibiotic, and the role of oxacillin characteristics and uses are very similar to the drug-resistant Staphylococcus aureus the product has bactericidal effect. Oral or intramuscular absorption is better, the blood concentration is 2 times higher than oxacillin, mainly used for infections caused by resistant Staphylococcus aureus, such as sepsis, osteomyelitis, skin and soft tissue infections, endocarditis, the curative effect of urinary system infection and meningitis is better. |
Sodium cloxacillin monohydrate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
Sodium cloxacillin monohydrate - Cloxacillin sodium liposome preparation for injection and preparation method
from Baidu Library
Application (patent) number:
CN201110229606.9
application date:
2011-08-11
Public/Announcement Number:
CN102397251A
Public/announcement date:
2012.04.04
applicant (patent):
Fu Miao Qing
inventor:
National and provincial code:
CN330727
Abstract:
The invention relates to the technical field of medicine, and discloses a cloxacillin sodium liposome preparation for injection and a preparation method thereof, the above-mentioned cloxacillin sodium liposome preparation for injection comprises the following raw material components in parts by weight: 1 part of cloxacillin sodium; 3-5 parts of soybean lecithin; 1-2 parts of cholesterol; 0.2-0.8 parts of antioxidant; sorbitol 3-5 parts; Trehalose 0.5-2 parts. The product of the invention has high stability and small side effects, and will not be broken due to dehydration, fusion, ice crystal formation and the like in the freeze-drying process, and can maintain a good encapsulation rate after hydration and remelting, convenient transportation and storage of products.
Last Update：2024-01-02 23:10:35
Sodium cloxacillin monohydrate - Crystallization method of cloxacillin sodium
from Baidu Library
patent type:
invention patent
Application (patent) number:
CN201910724200.4
application date:
20190807
Public/Announcement Number:
CN110452254A
Public/announcement date:
20191115
applicant (patent):
Ruiyang Pharmaceutical Co., Ltd.
inventor:
Young Enough , peak , Huang Wentao , Liu Haifeng , Liu Liqiang
National and provincial code:
CN370323
Abstract:
The invention relates to a crystallization method of cloxacillin sodium, belonging to the technical field of drug synthesis, 3 O-chlorophenyl 5 methyl 4 isoxazolyl chloride and acetone mixed acylation reaction, after filtration add acetone, crystallization; The acylation reaction: 6 aminopenicillanic acid was acylated by adding 3 O-chlorophenyl 5 methyl 4 isoxazolyl chloride and acetone mixture under alkaline conditions. The present invention does not carry out the steps of acidification, dehydration, addition of sodium isooctanoate crystallization and the like, and saves the use of the solvent and auxiliary materials in the above steps, and achieves the purpose of saving the cost and forming salt in one step. The invention achieves the purpose of one-step salt formation, shortens the unnecessary process flow, improves the yield and shortens the process time.
Last Update：2023-08-16 22:09:50
Sodium cloxacillin monohydrate - Introduction
Clozacillin sodium monohydrate is a semi-synthetic antibiotic, a chlorinated derivative of oxacillin. Antibacterial cloxacillin sodium (Cloxacap) is the sodium salt of cloxacillin, penicillin enzyme resistant, acid resistant, semi-synthetic penicillin. Cloxacillin sodium exerts a bactericidal effect on susceptible microorganisms during the active proliferation stage. Cloxacillin sodium acts by inhibiting the biosynthesis of cell wall mucopeptides.
Last Update：2022-10-16 17:30:42
Sodium cloxacillin monohydrate - Solubility and crystal habit analysis of cloxacillin sodium
from Baidu Library
Author:
Abstract:
in order to solve the problem of incomplete crystal habit of cloxacillin sodium leading to product quality failure, and to provide basic data for optimizing the crystallization process, the solubility of cloxacillin sodium in ethanol, propanol, isopropanol and acetone was determined by dynamic method, the products with different crystal habits were analyzed by X-ray powder diffraction (XRD) and thermogravimetric analysis (TG-DTA). The results show that the solubility of cloxacillin sodium increases with the increase of temperature in the above four pure solvent systems, and the solubility data are well fitted by the thermodynamic equation of Apelblat. The optimal crystal habit of cloxacillin sodium obtained in different solvent systems is lamellar crystal habit, the crystal of cloxacillin sodium with different crystal habits is the same crystal form, and the dehydration temperature is 163 ℃.
Key words:
cloxacillin sodium solubility Crystal learning X-ray powder diffraction thermogravimetric analysis
DOI:
10.3969/j.issn.1003-9015.2020.00.001
year:
2020
Last Update：2023-08-16 22:09:50
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